By Florencio Zaragoza Dörwald
Such a lot syntheses within the chemical learn laboratory fail and typically require a number of makes an attempt ahead of continuing satisfactorily. Failed syntheses usually are not in simple terms discouraging and problematic, but additionally rate loads of money and time. Many disasters could, even though, be kept away from by way of realizing the structure-reactivity courting of natural compounds.
This textbook highlights the competing strategies and boundaries of crucial reactions utilized in natural synthesis. through permitting chemists to fast realize power difficulties this booklet can help to enhance their potency and success-rate. A needs to for each graduate scholar but in addition for each chemist in and academia.
1 natural Synthesis: basic Remarks
2 Stereoelectronic results and Reactivity
3 the soundness of natural Compounds
4 Aliphatic Nucleophilic Substitutions: tricky Electrophiles
5 The Alkylation of Carbanions
6 The Alkylation of Heteroatoms
7 The Acylation of Heteroatoms
8 Palladium-Catalyzed C-C Bond Formation
10 Monofunctionalization of Symmetric Difunctional Substrates